Dr. Gaurav Sahay
PI, Associate Professor
Gaurav Sahay is an Associate Professor in the Department of Pharmaceutical Sciences, College of Pharmacy at Oregon State University. Dr. Sahay completed his postdoctoral research with Prof. Robert Langer and Prof. Daniel Anderson at the Koch Institute for Integrative Cancer Research at MIT and received his Ph.D. from the University of Nebraska Medical Center under the mentorship of Prof. Alexander Kabanov. Dr. Sahay’s lab is developing novel nanotechnology-based platforms for effective delivery of messenger RNA therapeutics for treatment of rare disorders including cystic fibrosis, retinal degeneration and lysosomal storage disorders. He has done pioneering work to dissect the intracellular transport essential for nucleic acid delivery to the cytosol and developed methods to overcome endosomal barriers. He has more than 43 peer-reviewed publications in top tier journals including Nature, Nature Biotechnology, Nature Nanotechnology, Journal of Controlled Release, Nano Letters etc. He is the winner of a 2013 American Association of Pharmaceutical Scientists (AAPS) Postdoctoral Fellow Award, the 2015 Controlled Release Society (CRS) T. Nagai Award, a 2016 American Association of Colleges of Pharmacy (AACP) New Investigator Award, and a 2019 Oregon Health & Sciences University (OHSU) Distinguished Faculty Senate Award for Collaboration. He serves as the Principal Investigator on awards funded through the National Institutes of Health, Medical Research Foundation of Oregon, Moderna Therapeutics, Cystic Fibrosis Foundation, and OSU. He serves as a consultant and scientific advisory board member to several biotech and venture capital firms. He was the Chair of the 2018 NanoMedicine and Drug Delivery Symposium (NanoDDS, Portland, OR).
Chris is a research assistant and lab manager working in Dr. Sahay’s research laboratory. He was born in Albuquerque, New Mexico and moved to Hillsboro, Oregon when he was 9 years old. He received a B.S. degree in Microbiology with a minor in Chemistry in 2017 from Oregon State University. During undergrad, Chris conducted research in multiple labs at OSU where he helped optimize assays. In the Sahay lab, Chris is currently working on gene delivery using lipid nanoparticles. Outside of lab, Chris enjoys working out, rock climbing, and playing with Polo.
Dr. Yulia Eygeris
Yulia received a Specialist (BS/MS) degree in Organic Chemistry at Novosibirsk State University, Russia, where she was working of preparation of paramagnetic liquid crystals with Dr. Igor Kirilyuk. She then set her way to pursue PhD outside of Russia to broaden her research interests in materials chemistry and ended up trading the snows of Siberia for red rocks of Utah. In her PhD, she studied nanoporous self-assemblies of polymer-brush silica nanoparticles with Prof. Ilya Zharov at University of Utah. She is a recipient of several research awards, including President’s Award for Extraordinary Undergraduate Students and Curie Club Graduate Research Award for the outstanding research. She brought her expertise in organic synthesis and nanoparticle characterization to the Sahay lab, where she’s exploring lipid nanoparticle formulations. In her free time, she enjoys playing video games, sewing, and exploring Oregon wineries with her husband.
Dr. Anindit Mukherjee
Sr. Research Associate
Anindit is a research associate in the Sahay lab. He received his Ph.D. degree in Cellular and Integrative physiology from the University of Nebraska Medical center in 2012. As a post-doctoral researcher, he trained under Dr. Thomas Kleyman followed by stint with Dr. David Ellison and gained expertise on the regulation epithelial transport. In the Sahay lab, Anindit is focused on developing the lipid nanoparticle based nucleic acid delivery system as a viable therapy for normalizing ion channel and transporter activity in the diseased lung epithelia of cystic fibrosis patients.
Dr. Renee Ryals
Research Assistant Professor – OHSU
Renee was born and raised in Daytona Beach, Florida. She received her BS in Chemistry and her PhD in Molecular Cell Biology and Clinical and Translational Science at the University of Florida. Her dissertation focused on expanding the utility of AAV gene therapy for inherited retinal dystrophies by generating dual AAV vectors for the delivery of large transgenes. After graduation, Renee moved to Portland, Oregon for her post-doctoral training with Dr. Mark Pennesi where she evaluated neuroprotective agents and their ability to slow retinal degeneration in a light-induced retinopathy model. Currently, Renee is a Research Assistant Professor in the Department of Ophthalmology working alongside both Dr. Pennesi and Dr. Sahay in a combined effort to develop gene therapies for retinal degeneration. In her free time, Renee enjoys community and personal development. She enjoys finding opportunities to utilize her process-oriented facilitation and conflict resolution skills.
Dr. Mohit Gupta
Mohit pursued his Bachelor’s in Pharmacy from Delhi Institute of Pharmaceutical Sciences and Research, India. His strong interest in Medicinal Chemistry took him to National Institute of Pharmaceutical Education and Research, Mohali, where he completed his Master’s focusing on the design and synthesis of Cationic Amphiphilic Peptides as potential Antimicrobial Agents. Mohit then decided to come to United States to pursue his PhD in Medicinal Chemistry. His graduate work with Dr. Patrick Flaherty at Duquesne University included design and synthesis of novel molecules for the therapeutics of HIV, Cancer, and Cognitive Dysfunctions. As a Postdoctoral scholar in Dr. Sahay’s lab, he is working on developing novel ionizable lipid nanoparticles (LNPs) for gene delivery applications, particularly for Cystic Fibrosis and Ocular Disorders.
Marco is a graduate student in the department of Pharmaceutical Sciences. He received his B.S. in Biochemistry & Molecular Biology from the University of California, Davis in 2011. After a three-year stint in assay development at Life Technologies Corp., he worked in the Fathman laboratory at Stanford University exploring various mechanisms of T-cell anergy and activation as they relate to autoimmune disorders. In the Sahay Lab, he is exploring avenues of mRNA synthesis for in vivo gene therapy delivery approaches as well as trying to find drug/gene delivery solutions for the neural retina. Outside the lab, he enjoys astronomy, running, beer sampling and hanging out with his better half, Polo.
Jeonghwan is a graduate student and an amateur scuba diver who always dreams for diving into tropical water. David grew up in South Korea, and earned his bachelor’s degree in industrial pharmacy and the Korea pharmacist license while he studied in Yeungnam University, South Korea. He spent another two years for master’s degree in pharmacy in Prof. Jong Oh Kim’s laboratory to develop nanoparticles for anticancer drug delivery. After that, he worked as a formulation researcher for generic drugs in a pharmaceutical company for a while. A thirst for deep understanding in nanomedicine drove him to fly across Pacific ocean and join Sahay lab. His current research focus is developing better delivery systems for RNA therapeutics and their utilization in genetic diseases, including cystic fibrosis and cancers. In his free time, he listens to musics and tours local coffee shops in Portland.
Dylan is pursuing a master’s degree in Pharmaceutical Sciences. He is interested in automating nanoparticle assembly and nanoparticle mediated gene replacement therapy for ocular diseases. He has 17 years of experience in research labs that include clinical, for-profit, non-profit, and academic settings. He is listed as a co-author on 11 papers and as an inventor on one patent. He also serves as the Assistant Director of the OSU/CoP High Throughput Screening Services Lab.
Siddharth’s experience in both academia and industry ignited his passion for therapeutic research. He received his B. S. in Biomedical Engineering from The University of Utah where he was introduced to research. Siddharth’s main focus was a project developing polymer-drug conjugate combination therapy in Prof. Hamid Ghandehari’s laboratory. Subsequently, he furthered his education by pursuing a Master of Engineering at Cornell University. Here, he advanced his research experience, working on Halloysite nanotubes for drug delivery to circulating tumor cells (CTCs) in Prof. Michael King’s laboratory. These experiences allowed him to seamlessly transition to industry, where Sid worked on exciting R&D projects such as, polymeric nucleotide delivery systems, micellar chemotherapeutic delivery systems, as well as oral and targeted delivery of nanoparticles at Intezyne Technologies. The most exciting part of his experience at Intezyne was being able to take a transfection reagent kit, EZplex, from concept all the way to a commercial product. As part of the Sahay Lab, he is studying the mechanisms of uptake and endosomal escape of nanoparticles in a high-throughput fashion and developing novel polymer- and lipid-based delivery systems for RNA-therapeutics. Furthermore, he is utilizing state-of-the-art nanoparticle characterization and imaging techniques to dissect the nanoparticle structure-activity relationships to engineer materials with enhanced endosomal escape capabilities. Finally, Sid is utilizing these potent nanoparticles for gene therapy in the eye for the prevention of vision loss.
Sahay Lab Alumni
Ms. Ema Robinson
Ms. Abeer Eltanway
Ms. Deuhazney Coley
Dr. Anna Brown
Dr. Ashwani Kumar Narayana