Publications

Publications

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49. Kim J, Eygeris Y, Gupta M, Sahay G. Self-assembled mRNA vaccines. Adv Drug Deliv Rev. 2021 Mar;170:83-112. doi: 10.1016/j.addr.2020.12.014.

48. Herrera M, Kim J, Eygeris Y, Jozic Antony, Sahay G. Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery. Biomater. Sci., 2021,9, 4289-4300. doi: 10.1101/2020.12.02.407601.

47. Mukherjee A, MacDonald KD, KIm J, Henderson MI, Eygeris Y, Sahay G. Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis-based cell and mice models. Science Advances. 2020 Nov 18;6(47):eabc5911. doi: 10.1126/sciadv.abc5911.

46. Ryals RC, Patel S, Acosta C, McKinney M, Pennesi ME, Sahay G. The effects of PEGylation on LNP based mRNA delivery to the eye. PLoS One. 2020 Oct 29;15(10):e0241006. doi: 10.1371/journal.pone.0241006.

45. Kim J, Jozic A, Sahay G. Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery. Cell Mol Bioeng. 2020 May 26;13(5):1-12. doi: 10.1007/s12195-020-00619-y.

44. Kim J, Mukherjee A, Nelson D, Jozic A, Sahay G. Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-Cov-2. 2020 Jul 25:2020.07.24.205583. Preprint. doi: 10.1101/2020.07.24.205583.

43. Eygeris Y, Patel S, Jozic Antony, Sahay G. Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery. Nano Letters. 2020 Jun 10;20(6):4543-4549. doi: 10.1021/acs.nanolett.0c01386.

42. Patel S, A Narayana, Robinson E, Xia Y, Mihai C, Griffith JP, Hou S, Esposito AA, Ketova T, Welsher K, Joyal JL, Almarsson Ö, Sahay G. Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. Nature Communications 11, 983 (2020). doi: https://doi.org/10.1038/s41467-020-14527-2.

41. Rosch JG, Winter H, DuRoss AN, Sahay G, Sun C. Inverse-micelle synthesis of doxorubicin-loaded alginate/chitosan nanoparticles and in vitro assessment of breast cancer cytotoxicity. Colloid Interface Sci Commun. 2019 Jan;28:69-74. doi: https://doi.org/10.1016/j.colcom.2018.12.002.

40. Sahay G. NanoDDS 2018: Engineering the next wave of nanomedicine and drug delivery systems. Adv Drug Deliv Rev. 2019 Apr;144:1-2. doi: https://doi.org/10.1016/j.addr.2019.09.001.

39. Patel S, Kim J, Herrera M, Mukherjee A, Kabanov A, Sahay G. Brief update on Endocytosis of Nanomedicines. Advanced Drug Delivery Reviews. 2019 Aug 12; 144: 90-111 doi: https://doi.org/10.1016/j.addr.2019.08.004.

38. Hennink WE, Sahay G. NanoDDS 2018: The 16th International Nanomedicine & Drug Delivery Symposium. J Control Release. 2019 Sep 28;310:22-23. doi: https://doi.org/10.1016/j.jconrel.2019.08.009. Epub 2019 Aug 12.

37. Kim J, Narayana A, Patel S, Sahay G. Advances in intracellular delivery through supramolecular self-assembly of oligonucleotides and peptides. Theranostics. 2019 May 18;9(11):3191-3212. doi: https://doi.org/10.7150/thno.33921.

36. Patel S, Ryals RC, Weller KK, Pennesi ME, Sahay G. Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 2019 Jun 10;303:91-100. doi: https://doi.org/10.1016/j.jconrel.2019.04.015.

35. Lübtow MM, Nelke LC, Seifert J, Kühnemundt J, Sahay G, Dandekar G, Nietzer SL, Luxenhofer R. Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physicochemical characterization and evaluation in 2D and 3D in vitro models. J Control Release. 2019 Jun 10;303:162-180. doi: https://doi.org/10.1016/j.jconrel.2019.04.014.

34. Duross A, Neufeld MJ, Landry MR, Rosch J, Eaton CT, Sahay G, Thomas CR, Sun C. Micellar Formulation of Talazoparib and Buparlisib for Enhanced DNA Damage in Breast Cancer Chemoradiotherapy. ACS Appl Mater Interfaces. 2019 Apr 3;11(13):12342-12356. doi: https://doi.org/10.1021/acsami.9b02408.

33. Rosch JG, Brown AL, DuRoss AN, DuRoss EL, Sahay G, Sun C. Nanoalginates via Inverse-Micelle Synthesis: Doxorubicin-Encapsulation and Breast Cancer Cytotoxicity. Nanoscale Res Lett. 2018 Nov 3;13(1):350. doi: https://doi.org/10.1186/s11671-018-2748-2.

32. Brown AL, Winter H, Goforth AM, Sahay G, Sun C. Facile Synthesis of Ligand-Free Iridium Nanoparticles and Their In Vitro Biocompatibility. Nanoscale Res Lett. 2018 Jul 13;13(1):208. doi: https://doi.org/10.1186/s11671-018-2621-3.

31. Robinson E, MacDonald KD, Slaughter K, McKinney M, Patel S, Sun C, Sahay G. Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis. Mol Ther. 2018 Aug 1;26(8):2034-2046. doi: https://doi.org/10.1016/j.ymthe.2018.05.014. Epub 2018 Jun 15.

30. Brown AL, Kai MP, DuRoss AN, Sahay G, Sun C. Biodistribution and Toxicity of Micellar Platinum Nanoparticles in Mice via Intravenous Administration. Nanomaterials (Basel). 2018 Jun 7;8(6). pii: E410. doi: https://doi.org/10.3390/nano8060410.

29. Patel S, Athirasala A, Menezes PP, Ashwanikumar N, Zou T, Sahay G, Messenger RNA Delivery for Tissue Engineering and Regenerative Medicine Applications. Bertassoni LE. Tissue Eng Part A. 2019 Jan;25(1-2):91-112. doi: https://doi.org/10.1089/ten.TEA.2017.0444.

28. Ashwanikumar N, Plaut JS, Mostofian B, Patel S, Kwak P, Sun C, McPhail K, Zuckerman DM, Esener SC, Sahay G. Supramolecular self assembly of nanodrill-like structures for intracellular delivery. J Control Release. 2018 Jul 28;282:76-89. doi: https://doi.org/10.1016/j.jconrel.2018.02.041.

27. Patel S, Ashwanikumar N, Robinson E, DuRoss A, Sun C, Murphy-Benenato KE, Mihai C, Almarsson Ö, Sahay G. Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA. Nano Lett. 2017 Sep 13;17(9):5711-5718. doi: https://doi.org/10.1021/acs.nanolett.7b02664.

26. Stewart MP, Sharei A, Ding X, Sahay G, Langer R, Jensen KF. In vitro and ex vivo strategies for intracellular delivery. Nature. 2016 Oct 12;538(7624):183-192. doi: https://doi.org/10.1038/nature19764.

25. Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750. doi: https://doi.org/10.1038/srep31750.

24. Stewart MP, Lorenz A, Dahlman J, Sahay G. Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 May;8(3):465-78. doi: https://doi.org/10.1002/wnan.1377.

23. Jhunjhunwala S, Aresta-DaSilva S, Tang K, Alvarez D, Webber MJ, Tang BC, Lavin DM, Veiseh O, Doloff JC, Bose S, Vegas A, Ma M, Sahay G, Chiu A, Bader A, Langan E, Siebert S, Li J, Greiner DL, Newburger PE, von Andrian UH, Langer R, Anderson DG. Neutrophil Responses to Sterile Implant Materials. PLoS One. 2015 Sep 10;10(9):e0137550. doi: https://doi.org/10.1371/journal.pone.0137550.

22. Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T. Small RNA combination therapy for lung cancer. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3553-61. doi: https://doi.org/10.1073/pnas.1412686111.

21. Eltoukhy AA, Sahay G, Cunningham JM, Anderson DG. Niemann-Pick C1 Affects the Gene Delivery Efficacy of Degradable Polymeric Nanoparticles. ACS Nano. 2014 Aug 26;8(8):7905-13. doi: https://doi.org/10.1021/nn501630h.

20. Dahlman JE, Barnes C, Khan OF, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Singh Sandhu K, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AK, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Panigrahy D, Schroeder A, Koteliansky V, Langer R, Anderson DG. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol. 2014 Aug;9(8):648-55. doi: https://doi.org/10.1038/nnano.2014.84.

19. Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3955-60. doi: https://doi.org/10.1073/pnas.1322937111. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753.

18. Karagiannis ED, Urbanska AM, Sahay G, Pelet JM, Jhunjhunwala S, Langer R, Anderson DG. Rational design of a biomimetic cell penetrating peptide library.ACS Nano. 2013 Oct 22;7(10):8616-26. doi: https://doi.org/10.1021/nn4027382.

17. Alabi CA, Love KT, Sahay G, Yin H, Luly KM, Langer R, Anderson DG. Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12881-6. doi: https://doi.org/10.1073/pnas.1306529110.

16. Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol. 2013 Jul;31(7):653-8. doi: https://doi.org/10.1038/nbt.2614.

15. Heller DA, Levi Y, Pelet JM, Doloff JC, Wallas J, Pratt GW, Jiang S, Sahay G, Schroeder A, Schroeder JE, Chyan Y, Zurenko C, Querbes W, Manzano M, Kohane DS, Langer R, Anderson DG. Modular ‘click-in-emulsion’ bone-targeted nanogels.Adv Mater. 2013 Mar 13;25(10):1449-54. doi: https://doi.org/10.1002/adma.201202881.

14. Ma M, Chiu A, Sahay G, Doloff JC, Dholakia N, Thakrar R, Cohen J, Vegas A, Chen D, Bratlie KM, Dang T, York RL, Hollister-Lock J, Weir GC, Anderson DG. Core-shell hydrogel microcapsules for improved islets encapsulation.Adv Healthc Mater. 2013 May;2(5):667-72. doi: https://doi.org/10.1002/adhm.201200341.

13. Alabi CA, Sahay G, Langer R, Anderson DG. Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles. Integr Biol (Camb). 2013 Jan;5(1):224-30. doi: https://doi.org/10.1039/c2ib20155k.

12. Alabi CA, Love KT, Sahay G, Stutzman T, Young WT, Langer R, Anderson DG. FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes. ACS Nano. 2012 Jul 24;6(7):6133-41. doi: https://doi.org/10.1021/nn3013838.

11. Chen D, Love KT, Chen Y, Eltoukhy AA, Kastrup C, Sahay G, Jeon A, Dong Y, Whitehead KA, Anderson DG. Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation.J Am Chem Soc. 2012 Apr 25;134(16):6948-51. doi: https://doi.org/10.1021/ja301621z.

10. Schroeder A, Dahlman JE, Sahay G, Love KT, Jiang S, Eltoukhy AA, Levins CG, Wang Y, Anderson DG. Alkane-modified short polyethyleneimine for siRNA delivery. J Control Release. 2012 Jun 10;160(2):172-6. doi: https://doi.org/10.1016/j.jconrel.2011.11.030.

9. Siegwart DJ, Whitehead KA, Nuhn L, Sahay G, Cheng H, Jiang S, Ma M, Lytton-Jean A, Vegas A, Fenton P, Levins CG, Love KT, Lee H, Cortez C, Collins SP, Li YF, Jang J, Querbes W, Zurenko C, Novobrantseva T, Langer R, Anderson DG. Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):12996-3001. doi: https://doi.org/10.1073/pnas.1106379108.

8. Whitehead KA, Sahay G, Li GZ, Love KT, Alabi CA, Ma M, Zurenko C, Querbes W, Langer RS, Anderson DG. Synergistic Silencing: Combinations of Lipid-like Materials for Efficacious siRNA delivery. Mol Ther. 2011 Sep;19(9):1688-94. doi: https://doi.org/10.1038/mt.2011.141.

7. Luxenhofer R, Sahay G, Schulz A, Alakhova D, Bronich TK, Jordan R, Kabanov AV. Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles. J Control Release. 2011 Jul 15;153(1):73-82. doi: https://doi.org/10.1016/j.jconrel.2011.04.010.

6. Kim JO, Sahay G, Kabanov AV, Bronich TK. Polymeric Micelles with Ionic Cores Containing Biodegradable Cross-Links for Delivery of Chemotherapeutic Agents. Biomacromolecules. 2010 Apr 12;11(4):919-26. doi: https://doi.org/10.1021/bm9013364.

5. Sahay G, Alakhova DY, Kabanov AV. Endocytosis of nanomedicines. J Control Release. 2010 Aug 3;145(3):182-95. doi: https://doi.org/10.1016/j.jconrel.2010.01.036. Review.

4. Sahay G, Gautam V, Luxenhofer R, Kabanov AV. The utilization of pathogen-like cellular trafficking by single chain block copolymer. Biomaterials. 2010 Mar;31(7):1757-64. doi: https://doi.org/10.1016/j.biomaterials.2009.11.020.

3. Sahay G, Kim JO, Kabanov AV, Bronich TK. The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents. Biomaterials. 2010 Feb;31(5):923-33. doi: https://doi.org/10.1016/j.biomaterials.2009.09.101.

2. Yang Z, Sahay G, Sriadibhatla S, Kabanov AV. Amphiphilic Block Copolymers Enhance Cellular Uptake and Nuclear Entry of Polyplex-Delivered DNA. Bioconjug Chem. 2008 Oct;19(10):1987-94. doi: https://doi.org/10.1021/bc800144a.

1. Sahay G, Batrakova EV, Kabanov AV. Different Internalization Pathways of Polymeric Micelles and Unimers and Their Effects on Vesicular Transport. Bioconjug Chem. 2008 Oct;19(10):2023-9. doi: https://doi.org/10.1021/bc8002315.