Our Team

Dr. Gaurav Sahay

PI, Assistant Professor

Gaurav Sahay is an Assistant Professor in the College of Pharmacy at Oregon State University/Oregon Health Science University in Portland, Oregon. Dr. Sahay completed his postdoctoral research with Prof. Robert Langer and Prof. Daniel Anderson at Koch Institute for Integrative Cancer Research at MIT. He received his PhD from the Lab of Dr. Alexander Kabanov at the University of Nebraska Medical Center (UNMC). His work is at the interface of nanotechnology, cell biology and drug delivery. Dr. Sahay is interested in unlocking the molecular mechanisms involved in the intracellular transport and endosomal escape of nanoparticles to deliver small molecules, nucleic acids etc. inside cells. Sahay lab has developed novel nanotechnologies for efficient intracellular delivery of therapeutics for the treatment of lysosomal storage disorders and cancer. He has 21 publications in top tier journals including Nature Biotechnology, Nature Nanotechnology, PNAS, Advanced Materials, ACS Nano etc. He is the winner of 2013 AAPS Postdoctoral Fellow Award, Nature’s Sci-Bx Innocentive challenge and 2015 CRS Nagai Postdoctoral Award.

Dr. Anna Brown

Post Doctoral Scholar

Anna Brown grew up and Sunny Southern California, and headed for the wet and green Pacific Northwest as soon as she could. She majored in Biochemistry and Molecular biology at Reed College, spent a couple of years working around Portland and teaching English at the Chinese Academy of Science in Wuhan, before getting a Ph.D in Chemistry from Portland State University. During her graduate work with Dr. Andrea Goforth, she focused on synthesis of bismuth nanoparticles as heavy metal inorganic X-ray contrast agents. From this research she co-founded a start-up company to commercialize some of these materials.

Her current research interests as a post-doc are nanomaterial synthetic strategies and material engineering for biological/medical applications. In the Sahay lab she is working with biofunctional lipids as therapeutics and delivery vectors. She additionally works with Dr. Conroy Sun on heavy metal inorganic nanoparticles for radiation therapeutic applications. In her free time she makes soap, practices Tae Kwon Do and wrangles her two dogs.

Siddarth Patel, M.

Engineering Graduate Student

Siddharth’s experience in both academia and industry ignited his passion for therapeutic research. He received his B. S. in Biomedical Engineering from The University of Utah where he was introduced to research. Siddharth's main focus was a project developing polymer-drug conjugate combination therapy in Prof. Hamid Ghandehari’s laboratory. Subsequently, he furthered his education by pursuing a Master of Engineering at Cornell University. Here, he advanced his research experience, working on Halloysite nanotubes for drug delivery to circulating tumor cells (CTCs) in Prof. Michael King’s laboratory. THese experiences allowed him to seamlessly transition to industry, where Sid worked on exciting R&D projects such as, polymeric nucleotide delivery systems, micellar chemotherapeutic delivery systems, oral and targeted delivery of nanoparticles at Intezyne Technologies. The most exciting part of his experience at Intezyne was being able to take a transfection reagent kit, EZplex, from concept all the way to a commercial product. As part of the Sahay Lab, he is developing novel polymer and lipid-based delivery systems for RNA-therapeutics, along with conducting high throughput screening to elucidate mechanisms for uptake and endosome escape of nanoparticles.

Ema Robinson, B.A.

Faculty Research Assistant

Ema began studying science at Reed College where she earned her degree in Biochemistry & Molecular Biology. As an undergraduate Ema studied human copper metabolism and Wilson's Disease at OHSU with Dr. Martina Ralle. Here she was privileged to work with a wide variety of analytical instrumentation, sparking her passion for experimental precision and assay development. Ema then went on to become the first laboratory employee for local biotechnology startup AbSci, LLC producing biosimilar drugs using a novel E. coli expression vector. Of her work at AbSci, she is most proud of her work on a high-throughput method for fab expression, purification, and quantification. In the Sahay lab, Ema assists in nanoparticle uptake and endosome escape research.

In her free time, Ema enjoys paragliding, climbing, skiing, and the amateur meteorology requisite for those activities. Lately, she has been learning French and studying wilderness survival. She believes strongly in Pasteur's comment that chance favors the prepared mind both in and out of science.

Ashwani Kumar Narayana, Ph.D

Post Doctoral Scholar

Ashwani Kumar received his Ph.D in Chemistry from the Rajiv Gandhi Centre for Biotechnology in Trivandrum, India where he worked with Dr.GS Vinod Kumar in developing novel nano drug delivery systems for 5-Fluorouracil. His research has focused on the development of nanomaterials comprised of polymeric and peptide backbones for drug delivery applications. His synthetic strategy has been mainly focused on solid phase peptide synthesis, free radical polymerization, and condensation polymerization. It is remarkable that Dr Kumar was able to synthesize self assembling peptide nanomaterials and polymers for a number of coherent drug (5-Fluorouracil) delivery systems with a high degree of specificity and selectivity in colon cancer chemotherapy. He has published his results in many journals including Acta Biomaterialia, Colloids and surfaces .B: Biointerfaces, RSC Advances, and Int. J Nanomedicine. He is also the recipient of numerous awards including MR Das Carrer award for the best Ph.D thesis and the Sathyabhama Devi Roy Gold medal for the topper in MSc Chemistry.

In Sahay Lab Ashwani is working in developing an effective nanoformulation of lipid nano particles (LNP) for the delivery of mRNA. He will also initiate the chemistry synthesis wing within the lab and provide his expertise in training undergraduate and graduate students in synthetic chemistry.

Lab Alumni

Ms. Anna Lorenz, M.S.

Ms. Abeer Eltanway

Ms. Deuhazney Coley